Immunoglobulins (Ig), which exist either as B-cell receptors (BCR) on the surface of B cells or as antibodies when secreted, play a key role in the recognition and response to antigenic threats. The ...

Bulk RNA sequencing (RNA-seq) of blood is typically used for gene expression analysis in biomedical research but is still rarely used in clinical practice. In this study, we propose that RNA-seq ...

Immunology researchers are working to understand complex adaptive immune responses, but meaningful signals are often rare, transient, or difficult to capture across large, sample-limited studies.

The R21/Matrix-M vaccine produces antibodies that bind to a specific site on a key protein of the malaria parasite. The R21/Matrix-M malaria vaccine generates nearly identical antibodies as those ...

Aim: To investigate how pediatric adaptive, innate immune memory and trained immunity alter viral pathogenesis. Techniques: Single-cell RNA sequencing (scRNA-seq), T and B cell receptor (TCR/BCR) ...