The detection of cytosolic DNA by the sensor cGAS triggers potent antiviral responses. New data now propose that cGAS is regulated on a post-translational level by glutamylation. Glutamylation is a ...

Cyclic GMP-AMP synthase (cGAS) functions as a foreign DNA sensor, triggering an immune response to pathogens by activating the STING (stimulator of interferon genes) receptor. Shortly after its ...

The new Transcreener cGAMP cGAS Assay directly measures the product cGAMP, in a cGAS enzymatic reaction allowing researchers to screen vast compound libraries for modulators of the enzyme. The assay ...

As people age, chronic inflammation can ensue. What drives this so-called “inflammaging”? A study published August 2 in Nature may have identified a primary cause, at least in the mouse brain.

WALTHAM, Mass. & MONTREAL--(BUSINESS WIRE)--Ventus Therapeutics, a clinical-stage biopharmaceutical company advancing two Phase 2 small-molecule programs for immunological, inflammatory, and ...