Researchers can use messenger RNA to trigger the immune system to attack tumors. By stimulating cancer cells to produce a molecule that activates a signaling pathway in nearby immune cells, MIT (MA, ...
CAMBRIDGE, MA -- By stimulating cancer cells to produce a molecule that activates a signaling pathway in nearby immune cells, MIT researchers have found a way to force tumors to trigger their own ...
Evaluating the immune landscape in early onset colorectal cancer patients. This is an ASCO Meeting Abstract from the 2025 ASCO Annual Meeting I. This abstract does not include a full text component.
The researchers used lipid nanoparticles (LNPs) to deliver cyclic GMP-AMP (cGAMP) synthase (cGAS) mRNA to cancer cells. This results in production of the endogenous stimulator of interferon genes ...
Activating this signaling pathway, known as the cGAS-STING pathway, worked even better when combined with existing immunotherapy drugs known as checkpoint blockade inhibitors, in a study of mice. That ...
The cGAS-STING signaling pathway has emerged as a major focus in cancer immunotherapy because it stimulates interferon production and enhances antitumor immune responses. However, despite strong ...
Researchers have been exploring ways to activate the cGAS/STING pathway in tumors as a way to slow their growth.
Our cells harbor a DNA detector termed cGAS to inform the immune system of viral and bacterial infections, cell death, as well as transformation during cancer. Researchers led by Ikerbasque Research ...
Cancer immunotherapy has historically focused on harnessing the ability of T cells to recognize and attack cancer cells. Adaptive immune checkpoint inhibitors (ICIs) unleash tumor-infiltrating ...
Some results have been hidden because they may be inaccessible to you
Show inaccessible results