Researchers at Texas A&M University reported that two intranasal doses of extracellular vesicles derived from human neural ...

Activating this signaling pathway, known as the cGAS-STING pathway, worked even better when combined with existing immunotherapy drugs known as checkpoint blockade inhibitors, in a study of mice. That ...

Researchers have been exploring ways to activate the cGAS/STING pathway in tumors as a way to slow their growth.

The cGAS-STING signaling pathway has emerged as a major focus in cancer immunotherapy because it stimulates interferon production and enhances antitumor immune responses. However, despite strong ...

Army Medical University has identified new cyclic GMP-AMP synthase (MB21D1; cGAS)/STING pathway inhibitors potentially useful for the treatment of inflammatory disorders.

The researchers used lipid nanoparticles (LNPs) to deliver cyclic GMP-AMP (cGAMP) synthase (cGAS) mRNA to cancer cells. This results in production of the endogenous stimulator of interferon genes ...