The cGAS-STING pathway is emerging as a key driver of chronic neuroinflammation through its effects on glial activation, neuronal stress, blood-brain barrier integrity, and type I interferon signaling ...
The activation of microglia and the resulting neuroinflammation play crucial regulatory roles in the pathogenesis and progression of neurological diseases, although the specific mechanisms remain ...
Aging is often accompanied by chronic, low-grade inflammation, termed inflammaging. Recent evidence suggests that the cGAS/STING signaling pathway, which mediates immune sensing of DNA, is a critical ...
Army Medical University has identified new cyclic GMP-AMP synthase (MB21D1; cGAS)/STING pathway inhibitors potentially useful for the treatment of inflammatory disorders.
Researchers have been exploring ways to activate the cGAS/STING pathway in tumors as a way to slow their growth.
Evaluating the immune landscape in early onset colorectal cancer patients. This is an ASCO Meeting Abstract from the 2025 ASCO Annual Meeting I. This abstract does not include a full text component.
The researchers used lipid nanoparticles (LNPs) to deliver cyclic GMP-AMP (cGAMP) synthase (cGAS) mRNA to cancer cells. This results in production of the endogenous stimulator of interferon genes ...
A novel nasal spray-based approach to deliver therapeutic miRNA-laden extracellular vesicles could combat neuroinflammaging and the decline of aging brains. Researchers at the Texas A&M University ...
A new review brings attention to the STING pathway as a critical regulator in both colitis and colon cancer, highlighting its complex and often opposing roles in inflammation and tumor development.
This illustration depicts as human STING protein signaling progresses from inactive to overactive, it can trigger an unwanted immune response — a progression not found in mouse models. Researchers ...
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