Our food and our bodies are full of tiny protein fragments called peptides. These small chains of amino acids act as ...

The sequencing of the human genome has been a scientific landmark achievement, and it has had major implications for our understanding of human health 1. However, excluding contributing factors from ...

Despite advances in mass spectrometry and emerging single-molecule approaches, sequencing peptides at the single-molecule level remains a central challenge in proteomics. Here we present a ‘reverse ...

Proteins, one of the smallest building blocks of life on Earth, hold promise for answering some of biology's biggest questions. Consisting of amino acids strung together into peptide chains, these ...

A new single-cell technology is giving scientists their clearest view yet of immune cell behavior—capturing not just genetic intent, but real-time activity. By measuring RNA and proteins ...

Proteomics—a term first coined in the mid-1990s—refers to the study of the complete set of proteins expressed in a cell, tissue, or organism. In contrast to genomics and transcriptomics, proteomics is ...

A new technology to enable the simultaneous performance of proteomics and genomics has been developed. An innovative new technique from the Andalusian Centre for Molecular Biology and Regenerative ...

Textbooks often depict proteins in one conformation, but real life, as usual, is much messier. While some proteins have stable, unchanging structures, many others have intrinsically disordered regions ...

Nucleic acid-based therapeutics, including antisense oligonucleotides (ASO), small interfering RNA (siRNA), messenger RNA (mRNA), immunomodulatory DNA/RNA, and gene-editing guide RNA (gRNA), hold ...

Proteins, one of the smallest building blocks of life on Earth, hold promise for answering some of biology’s biggest questions. Consisting of amino acids strung together into peptide chains, these ...