The renin–angiotensin–aldosterone system (RAAS) is a hierarchical endocrine cascade that governs arterial pressure, vascular tone and sodium–water balance, thereby exerting profound influence on ...

Aging is associated with an imbalance in sympathetic and parasympathetic outflow to cardiovascular effector organs. This autonomic imbalance contributes to the decline in cardiovagal baroreceptor ...

The argument was elegant in its simplicity. Patients with high levels of renin had a vasoconstriction type of hypertension that was driven primarily by the actions of the renin-angiotensin system on ...

Initial evidence of the existence of renin, which is an angiotensinogenase enzyme secreted by the kidney, was presented to the medical community more than 100 years ago. Nevertheless, the significance ...

THE role of the kidney in the regulation of blood pressure through the mediation of renin was first suggested by the classic experiments of Goldblatt. 1 Although there was considerable initial ...

Objective While guidelines advocate renin-angiotensin system inhibitors (RASi) for renoprotection in lupus nephritis (LN), ...

Cost-effectiveness of NALIRIFOX compared to other first-line treatments for metastatic pancreatic cancer. This is an ASCO Meeting Abstract from the 2025 ASCO Gastrointestinal Cancers Symposium. This ...

a Multivariate model adjusting for cancer therapy including antimetabolites, Vascular endothelial growth factors inhibitors, taxanes, tyrosine kinase inhibitors, monoclonal antibodies, vinca alkaloids ...

Three large randomized trials tested a simple idea: if one blood-pressure drug that blocks the renin-angiotensin system ...

High blood pressure, also called hypertension, is one of the most common health problems in the world. Millions of people ...

Angiotensin receptor blockers are antihypertensive medicines used to treat high blood pressure. They act as vasodilators, widening the blood vessels (vasodilation) and reducing blood pressure. The ...