Germline and somatic variants are inherently connected. All germline variants originate as de novo somatic mutations either in parental germ cells or very early in embryonic development. As such, ...

A genetic difference carried by nearly one in three people may increase the risk of severe COVID-19 and lung fibrosis by ...

Genetic divergence and adaptive variation constitute the foundation of evolutionary change in natural populations. Divergence arises when populations accumulate distinct allele frequencies through ...

Structural variants (SVs) are alterations in the DNA sequence that involve large-scale changes, typically longer than 50 base pairs. Advances in long-read sequencing have significantly increased ...

Genome assemblies from 65 individuals, representing a variety of the world’s populations, are advancing the scientific exploration of complex genetic structural variation. Structural variations are ...

Knowing how human DNA changes over generations is essential to estimating genetic disease risks and understanding how we evolved. But some of the most changeable regions of our DNA have been ...

The great majority of how we understand human disease, and attempt to cure it, derives from mice genetically fashioned to be prolific breeders, docile and easy to handle—all qualities that have made ...

Graft a patch of skin from one wild cheetah onto another, unrelated cheetah, and the recipient’s body will not reject it.

Nomic Bio Inc. announced a research collaboration with the Wellcome Sanger Institute to perform large-scale proteomic ...

April 10 (Reuters) - Weight-loss responses to GLP-1 obesity drugs, and risks of side effects, may be linked to genetic variants, according to a study conducted by DNA-testing service 23AndMe. The ...