Frontiers

Innate immune signaling and inflammatory amplification in inflammation-driven diseases: mechanisms, biomarkers, and therapeutic targeting

Inflammation immunology has emerged as a central field for understanding the balance between host defense and pathological immune activation.
BioWorld

Tricylic agonist of cGAS/STING signaling tested by Curadev Pharma researchers

Researchers have been exploring ways to activate the cGAS/STING pathway in tumors as a way to slow their growth.
BioWorld

Army Medical University reports new cGAS/STING pathway inhibitors

Army Medical University has identified new cyclic GMP-AMP synthase (MB21D1; cGAS)/STING pathway inhibitors potentially useful for the treatment of inflammatory disorders.
ascopubs.org

Effect of cyclin E overexpression on anti-tumor immune responses via activation of the cGAS/STING pathway following radiotherapy.

Evaluating the immune landscape in early onset colorectal cancer patients. This is an ASCO Meeting Abstract from the 2025 ASCO Annual Meeting I. This abstract does not include a full text component.
GEN

Cancer Cell Enzyme Activates Antitumor Immune Pathway

The researchers used lipid nanoparticles (LNPs) to deliver cyclic GMP-AMP (cGAMP) synthase (cGAS) mRNA to cancer cells. This results in production of the endogenous stimulator of interferon genes ...