Mechanistic hypotheses implicate JAK2 inhibition–mediated impairment of macrophage cholesterol efflux, and the signal ...
Heart disease is still the leading cause of death worldwide, and high cholesterol is a major driver of that problem.
A powerful cholesterol-lowering drug may be changing the rules of heart disease prevention. Researchers found that evolocumab, typically used for people who already have cardiovascular disease, can ...
Cholesterol synthesis is governed by transcriptional and posttranslational feedback mechanisms that maintain sterol balance. This study identifies a previously unrecognized regulatory connection ...
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