Radiation therapy remains a central modality in cancer treatment, but normal-tissue toxicity and long-term stochastic effects ...

The mechanical process of cell division exerts powerful, if microscopic, forces. How do the molecular machines that power it ...

Base editing in human embryos reveals that NANOG is the one gene required to form every body tissue. Cambridge’s landmark ...

Newborn mice neurons can snap both DNA strands to migrate, then repair the breaks within a day. The process may be a normal ...

Researchers have discovered that a gene normally responsible for repairing damaged DNA may actually contribute to ...

Scientists have, for the first time, used an extremely precise genome editing technique called base editing to study gene ...

Researchers led by developmental biologist Kathy Niakan at the University of Cambridge have used base editing in human embryos to learn more about human embryonic development. By deactivating a gene ...

DNA Damage Response (“DDR”) inhibitors, a category of drugs that work by blocking cancer cells' capacity to fix their own damaged DNA, are growing well beyond the poly ADP ribose polymerase (“PARP”) ...

New brain cells may briefly damage their own DNA as they squeeze through the crowded developing brain, according to a new ...

The class of drugs known as DNA Damage Response inhibitors, which work by blocking cancer cells’ ability to repair their own damaged DNA, is expanding rapidly beyond its original anchor, the PARP ...

Researchers found that newborn neurons experience widespread DNA double-strand breaks as they squeeze through crowded brain ...