No, not a puppy or a kitten or even a pet turtle, but a PET tracer to visualize huntingtin (HTT) protein in living subjects. PET stands for Positron Emission Tomography, an imaging technique that can ...
On June 30th, Skyhawk Therapeutics shared a press release with new twelve-month data from the ongoing Phase 1/2 trial of ...
SKY-0515 is a daily oral drug designed to lower both huntingtin, the protein that drives HD, and PMS1, a DNA repair protein linked to somatic CAG repeat expansion. Researchers hope this dual-target ...
In a recent study, scientists created a chemical that breaks down expanded huntingtin HTT clumps in HD cells and mouse models. This chemical finds HTT clumps and targets them to be broken down or ...
Huntington’s disease (HD) involves the loss of cells in the striatum, an area of the brain that plays important roles in movement, cognition, and behaviour. For decades, researchers have been ...
A new study shows that lowering a harmful piece of the huntingtin message (Htt1a) appears effective at reducing HD-related symptoms in mice, perhaps more so than targeting full length HTT. Whether ...
When it comes to clearing up the mess created by mutant Huntingtin (HTT) we tend to think of sending external help into the brain, in the form of HTT lowering drugs or anti-sense oligonucleotides ...
When most people picture scientists doing experiments in labs, they imagine mice in mazes or cells growing in petri dishes. But for complex conditions like Huntington’s Disease (HD), these simple ...
The Total Functional Capacity scale, or TFC, was developed in 1979 by researchers Dr. Stanley Fahn and the late Dr. Ira Shoulson, founder of the Huntington Study Group. They wanted to describe the ...
Artificial Intelligence, or AI, has become an everyday feature of the world we live in. Internet browsers have an ‘AI mode’ and even our refrigerators and vacuum cleaners now include AI features!
Anew study using precise gene editing in a Huntington’s disease (HD) mouse model provides evidence that a small fragment of the huntingtin (HTT) protein, called HTT1a, is a central driver of HD. By ...
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